THE JOURNAL OF CLINICAL INVESTIGATION

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The JCI is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.

May 2008: View the entire issue

Cover story: Walking on AIRE
H&E-stained section of the thyroid gland. Individuals develop the autoimmune disease autoimmune polyglandular syndrome type 1 (APS 1) if both copies of their AIRE gene are mutated such that they make no functional AIRE protein. Many different mutations in the AIRE gene have been linked to APS1. Individuals with a mutation known as G228W in just one copy of their AIRE gene have been identified and shown to exhibit a different pattern of symptoms to individuals with APS1. Insights into the mechanisms, especially in the thymus, by which the G228W mutation causes autoimmunity have now been provided by Maureen Su and colleagues (page 1712).

Also inside:

Could PPAR-γ antagonists be used to treat AIDS?

Regulating the hypothalamic-pituitary-gonad axis

IFN-β can prevent autoimmune disease mediated by Th17 cells

PI3K signaling is essential for leptin to signal in the hypothalamus

Global Health

Series funded by an unrestricted educational grant from the Bill and Melinda Gates Foundation

Although advances in science and technology have resulted in substantial improvements in the health of individuals in the developed world, similar progress has not been observed for those living in the developing world. This Review Series focuses on the health conditions that affect people living in the developing world, and it highlights some of the areas that require attention if these conditions are either to be brought under control or eradicated.

Molecular Mechanisms of Stress

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Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking

Jessie R. Zhang, Trey Coleman, S. Joshua Langmade, David E. Scherrer, Lindsay Lane, M. Hunter Lanier, Chu Feng, Mark S. Sands, Jean E. Schaffer, Clay F. Semenkovich, and Daniel S. Ory

Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice

Serena Zacchigna, Lucia Pattarini, Lorena Zentilin, Silvia Moimas, Alessandro Carrer, Milena Sinigaglia, Nikola Arsic, Sabrina Tafuro, Gianfranco Sinagra, and Mauro Giacca

Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits

Lea Scheppke, Edith Aguilar, Ray F. Gariano, Ruth Jacobson, John Hood, John Doukas, Jon Cao, Glenn Noronha, Shiyin Yee, Sara Weis, Michael B. Martin, Richard Soll, David A. Cheresh, and Martin Friedlander

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice

Meilin Wu, Jun Li, Kurt A. Engleka, Bo Zhou, Min Min Lu, Joshua B. Plotkin, and Jonathan A. Epstein

Helicobacter pylori induces β3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x

Nuno T. Marcos, Ana Magalhães, Bibiana Ferreira, Maria J. Oliveira, Ana S. Carvalho, Nuno Mendes, Tim Gilmartin, Steven R. Head, Céu Figueiredo, Leonor David, Filipe Santos-Silva, and Celso A. Reis

A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition

Alberto J. Schuhmacher, Carmen Guerra, Vincent Sauzeau, Marta Cañamero, Xosé R. Bustelo, and Mariano Barbacid

Leaky Ca²⁺ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

Stephan E. Lehnart, Marco Mongillo, Andrew Bellinger, Nicolas Lindegger, Bi-Xing Chen, William Hsueh, Steven Reiken, Anetta Wronska, Liam J. Drew, Chris W. Ward, W.J. Lederer, Robert S. Kass, Gregory Morley, and Andrew R. Marks

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