THE JOURNAL OF CLINICAL INVESTIGATION

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The JCI is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.

September 2008: View the entire issue

Cover story: Modeling human-pathogen interactions in Drosophila
Fruit fly Drosophila melanogaster. Quorum sensing enables bacteria to communicate within and among species, and the molecule 3OC12-HSL is thought to play a central role in this system. Stoltz and colleagues investigated the role of 3OC12-HSL and one of the human enzymes that degrade it, PON1, in Pseudomonas aeruginosa virulence in the fruit fly — a tractable model for investigating the host-pathogen interaction as it lacks PONs. The authors show that human PON1 expression protected the flies from P. aeruginosa lethality by disrupting 3OC12-HSL–mediated quorum-sensing pathways used by this pathogen.
Image credit: Photo Researchers Inc.

Also inside:

Overcoming cancer cell drug resistance

Humanized mice to help understand drug metabolism

Hepatic control of detrimental effects of a high-fat diet

Protecting dopaminergic neurons in Parkinson disease

Global Health

Although advances in science and technology have resulted in substantial improvements in the health of individuals in the developed world, similar progress has not been observed for those living in the developing world. This Review Series focuses on the health conditions that affect people living in the developing world, and it highlights some of the areas that require attention if these conditions are either to be brought under control or eradicated.

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